| ncRNA name | rno-miR-195 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | human umbilical vein endothelial cells (HUVECs), human retinal endothelial cells (HMRECs), 293A cell line |
| Methods | microarray, Western blot, luciferase reporter assay, immunohistochemistry |
| Expression pattern | up-regulated |
| Functional description | Overexpression of miR-195 reduced MFN2 protein levels, and induced tube formation and increased permeability of diabetic retinal vasculature. The luciferase reporter assay confirmed that miR-195 binds to the 3' -untranslated region (3'-UTR) of MFN2 mRNA. |
| PubMed ID | 28487236 |
| Year | 2017 |
| Title | Upregulation of miR-195 accelerates oxidative stress-induced retinal endothelial cell injury by targeting mitofusin 2 in diabetic rats. |
| Drug-related ncRNA | NO |
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